Clement Kleinstreuer

Professor

Adjunct Professor of Biomedical Engineering, NCSU and UNC Chapel Hill

Professor Kleinstreuer’s long-term goal is to provide students with a high-quality education in engineering and to perform cutting-edge research that responds to national needs in science and technology.

He recently developed the graduate-level course entitled “Modern Topics in Fluid Dynamics” (MAE 589K). This course treats such modern topics as microfluidics, bio-fluids, and nanofluid flow. At the undergraduate level, he teaches Engineering Thermodynamics I (MAE 301) as well as Fluid Mechanics (MAE 308). Although these are courses that follow a classical coverage of material, he also presents energy transfer and fluid-particle flow animations to help students visualize the different phenomena being treated. Furthermore, Student White-Board Performance (SW-BP) is an integral feature of advanced learning.

As a faculty advisor, Dr. Kleinstreuer guides his students to meet industrial and academic challenges. His students have a strong knowledge base in physics, applied mathematics, and gain a strong foundation in computer modeling of complex multi-physics phenomena.

Outside of work, Dr. Kleinstreuer enjoys family activities such as tennis, chess, sailing, and the arts.

Education

Ph.D.

Vanderbilt University

M.S.

Stanford University

Dipl.Ing

Technical University, Munich

Research Description

Dr. Kleinstreuer is interested in computational biofluid mechanics, convection heat and mass transfer, and system optimization. He is presently studying computationally: 1) fluid-particle dynamics in the human respiratory system, including optimal targeting of inhaled drug aerosols; 2) radioactive micro-sphere transport in the hepatic system to reduce/eliminate liver tumors; 3) fluid-structure interaction in stented aneurysms, associated with rupture prediction and novel stent-graft design; and 4) nanofluid flow in micro-channels applied to cooling devices and bio-MEMS.

Publications

An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition
Feng, Yu and Zhao, Jianan and Kleinstreuer, Clement and Wang, Qingsheng and Wang, Jun and Wu, Dee H. and Lin, Jiang (2018), JOURNAL OF AEROSOL SCIENCE, 123(), 185-207.
Convective mass and heat transfer enhancement of nanofluid streams in bifurcating microchannels
Chari, Sriram and Kleinstreuer, Clement (2018), INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 125(), 1212-1229.
Direct nanodrug delivery for tumor targeting subject to shear-augmented diffusion in blood flow
Xu, Zelin and Kleinstreuer, Clement (2018), MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 56(11), 1949-1958.
Subject-variability effects on micron particle deposition in human nasal cavities
Calmet, H. and Kleinstreuer, C. and Houzeaux, G. and Kolanjiyil, A. V. and Lehmkuhl, O. and Olivares, E. and Vazquez, M. (2018), Journal of Aerosol Science, 115(), 12-28.
Computational analysis of aerosol-dynamics in a human whole-lung airway model
Kolanjiyil, A. V. and Kleinstreuer, C. (2017), Journal of Aerosol Science, 114(), 301-316.
Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model
Chen, X. L. and Feng, Y. and Zhong, W. Q. and Kleinstreuer, C. (2017), Journal of Aerosol Science, 105(), 108-127.
Computational nanofluid flow and heat transfer in microchannels
Kleinstreuer, C. (2016), Handbook of Fluid Dynamics, 2nd Edition, (), .
Computational transport, phase change and deposition analysis of inhaled multicomponent droplet-vapor mixtures in an idealized human upper lung model
Feng, Y. and Kleinstreuer, C. and Castro, N. and Rostami, A. (2016), Journal of Aerosol Science, 96(), 96-123.
Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation
Kolanjiyil, A. V. and Kleinstreuer, C. (2016), Computers in Biology and Medicine, 79(), 193-204.
Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model
Chen, X. L. and Zhong, W. Q. and Tom, J. and Kleinstreuer, C. and Feng, Y. and He, X. P. (2016), Particuology, 28(), 102-113.
Laminar/turbulent airflow and microsphere deposition in a patient-specific airway geometry using an open-source solver
Vaish, M. and Kleinstreuer, C. and Kolanjiyil, A. V. and Saini, N. and Pillalamarri, N. R. (2016), International Journal of Biomedical Engineering and Technology, 22(2), 145-161.
Microsystems and microfluidics
Kleinstreuer, C. (2016), Handbook of Fluid Dynamics, 2nd Edition, (), .
Solid tumor embolotherapy in hepatic arteries with an anti-reflux catheter system
Xu, Z. L. and Jernigan, S. and Kleinstreuer, C. and Buckner, G. D. (2016), Annals of Biomedical Engineering, 44(4), 1036-1046.
Computationally efficient fluid-particle dynamics simulations of arterial systems
Umbarkar, T. S. and Kleinstreuer, C. (2015), Communications in Computational Physics, 17(2), 401-423.
Evaporation and condensation of multicomponent electronic cigarette droplets and conventional cigarette smoke particles in an idealized G3-G6 triple bifurcating unit
Feng, Y. and Kleinstreuer, C. and Rostami, A. (2015), Journal of Aerosol Science, 80(), 58-74.
A Lagrangian approach for calculating microsphere deposition in a one-dimensional lung-airway model
Vaish, M. and Kleinstreuer, C. (2015), Journal of Biomechanical Engineering, 137(9), .
Computationally efficient particle release map determination for direct tumor-targeting in a representative hepatic artery system
Childress, E. M. and Kleinstreuer, C. (2014), Journal of Biomechanical Engineering, 136(1), .
Concentration photovoltaic-thermal energy co-generation system using nanofluids for cooling and heating
Xu, Z. L. and Kleinstreuer, C. (2014), Energy Conversion and Management, 87(), 504-512.
DDPM-DEM simulations of particulate flows in human tracheobronchial airways
Feng, Y. and Kleinstreuer, C. (2014), Proceedings of the ASME International Mechanical Engineering Congress and Exposition, 2013, vol 3B, (), .
Impact of fluid-structure interaction on direct tumor-targeting in a representative hepatic artery system
Childress, E. M. and Kleinstreuer, C. (2014), Annals of Biomedical Engineering, 42(3), 461-474.
Micron-particle transport, interactions and deposition in triple lung-airway bifurcations using a novel modeling approach
Feng, Y. and Kleinstreuer, C. (2014), Journal of Aerosol Science, 71(), 1-15.
Analysis of non-spherical particle transport in complex internal shear flows
Feng, Y. and Kleinstreuer, C. (2013), Physics of Fluids (Woodbury, N.Y.), 25(091904), .
Computational analysis of non-spherical particle transport and deposition in shear flow with application to lung aerosol dynamics: A review
Kleinstreuer, C. and Feng, Y. (2013), Journal of Biomechanical Engineering, 135(2), 0210081--02100819.
Critical invalidation of temperature dependence of nanofluid thermal conductivity enhancement
Han, K. and Lee, W. H. and Kleinstreuer, C. and Koo, J. (2013), Journal of Heat Transfer, 135(5), .
Lung deposition analyses of inhaled toxic aerosols in conventional and less harmful cigarette smoke: A review
Kleinstreuer, C. and Feng, Y. (2013), International Journal of Environmental Research and Public Health, 10(9), 4454-4485.
Nanoparticle mass transfer from lung airways to systemic regions-part I: Whole-lung aerosol dynamics
Kolanjiyil, A. V. and Kleinstreuer, C. (2013), Journal of Biomechanical Engineering, 135(12), .
Nanoparticle mass transfer from lung airways to systemic regions-part II: Multi-compartmental modeling
Kolanjiyil, A. V. and Kleinstreuer, C. (2013), Journal of Biomechanical Engineering, 135(12), .
A review of entropy generation in nanofluid flow
Mahian, O. and Kianifar, A. and Kleinstreuer, C. and Al-Nimr, M. A. and Pop, I. and Sahin, A. Z. and Wongwises, S. (2013), International Journal of Heat and Mass Transfer, 65(), 514-532.
Experimental microsphere targeting in a representative hepatic artery system
Richards, A. L. and Kleinstreuer, C. and Kennedy, A. S. and Childress, E. and Buckner, G. D. (2012), IEEE Transactions on Biomedical Engineering, 59(1), 198-204.
Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model
Zhang, Z. and Kleinstreuer, C. and Hyun, S. (2012), Journal of Aerosol Science, 46(), 34-52.
Thermal nanofluid property model with application to nanofluid flow in a parallel disk system-part II: Nanofluid flow between parallel disks
Feng, Y. and Kleinstreuer, C. (2012), Journal of Heat Transfer, 134(5), .
Thermal nanofluid property model with application to nanofluid flow in a parallel-disk system-part I: A new thermal conductivity model for nanofluid flow
Kleinstreuer, C. and Feng, Y. (2012), Journal of Heat Transfer, 134(5), .
Vapor deposition during cigarette smoke inhalation in a subject-specific human airway model
Zhang, Z. and Kleinstreuer, C. and Feng, Y. (2012), Journal of Aerosol Science, 53(), 40-60.
Airflow analysis in the alveolar region using the lattice-Boltzmann method
Li, Z. and Kleinstreuer, C. (2011), Medical & Biological Engineering & Computing, 49(4), 441-451.
Analysis of multi-layer immiscible fluid flow in a microchannel
Li, J. and Sheeran, P. S. and Kleinstreuer, C. (2011), Journal of Fluids Engineering-Transactions of the ASME, 133(11), .
Computational analysis of airflow and nanoparticle deposition in a combined nasal-oral-tracheobronchial airway model
Zhang, Z. and Kleinstreuer, C. (2011), Journal of Aerosol Science, 42(3), 174-194.
Deposition of naphthalene and tetradecane vapors in models of the human respiratory system
Zhang, Z. and Kleinstreuer, C. (2011), Inhalation Toxicology, 23(1), 44-57.
Experimental and theoretical studies of nanofluid thermal conductivity enhancement: A review (vol 6, pg 229, 2011)
Kleinstreuer, C. and Feng, Y. (2011), Nanoscale Research Letters, 6(), .
Impact analysis of natural convection on thermal conductivity measurements of nanofluids using the transient hot-wire method
Hong, S. W. and Kang, Y. T. and Kleinstreuer, C. and Koo, J. (2011), International Journal of Heat and Mass Transfer, 54(15-16), 3448-3456.
Optimal drug-aerosol delivery to predetermined lung sites
Kleinstreuer, C. and Zhang, Z. (2011), Journal of Heat Transfer, 133(1), .
A relation between near-wall particle-hemodynamics and onset of thrombus formation in abdominal aortic aneurysms
Basciano, C. and Kleinstreuer, C. and Hyun, S. and Finol, E. A. (2011), Annals of Biomedical Engineering, 39(7), 2010-2026.
Airflow and particle transport in the human respiratory system
Kleinstreuer, C. and Zhang, Z. (2010), Annual Review of Fluid Mechanics, 42(), 301-334.
Computer modeling of Yttrium-90-microsphere transport in the hepatic arterial tree to improve clinical outcomes
Kennedy, A. S. and Kleinstreuer, C. and Basciano, C. A. and Dezarn, W. A. (2010), International Journal of Radiation Oncology, Biology, Physics, 76(2), 631-637.
Computer modeling of controlled microsphere release and targeting in a representative hepatic artery system
Basciano, C. A. and Kleinstreuer, C. and Kennedy, A. S. and Dezarn, W. A. and Childress, E. (2010), Annals of Biomedical Engineering, 38(5), 1862-1879.
Entropy generation analysis for nanofluid flow in microchannels
Kleinstreuer, C. (2010), Journal of Heat Transfer, 132(12), .
Influence of aspect ratio on the dynamics of a freely moving circular disk
Shenoy, A. R. and Kleinstreuer, C. (2010), Journal of Fluid Mechanics, 653(), 463-487.
Nanofluid convective heat transfer in a parallel-disk system
Feng, Y. and Kleinstreuer, C. (2010), International Journal of Heat and Mass Transfer, 53(21-22), 4619-4628.
Comparison of analytical and CFD models with regard to micron particle deposition in a human 16-generation tracheobronchial airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2009), Journal of Aerosol Science, 40(1), 16-28.
Invariant-based anisotropic constitutive models of the healthy and aneurysmal abdominal aortic wall
Basciano, C. A. and Kleinstreuer, C. (2009), Journal of Biomechanical Engineering, 131(2), .
Microfluidics analysis of nanoparticle mixing in a microchannel system
Li, J. and Kleinstreuer, C. (2009), Microfluidics and Nanofluidics, 6(5), 661-668.
An adjustable triple-bifurcation unit model for air-particle flow simulations in human tracheobronchial airways
Kleinstreuer, C. and Zhang, Z. (2009), Journal of Biomechanical Engineering, 131(2), .
Airflow and nanoparticle deposition in a 16-generation tracheobronchial airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2008), Annals of Biomedical Engineering, 36(12), 2095-2110.
Computational mechanics of Nitinol stent grafts
Kleinstreuer, C. and Li, Z. and Basciano, C. A. and Seelecke, S. and Farber, M. A. (2008), Journal of Biomechanics, 41(11), 2370-2378.
Dilute suspension flow with nanoparticle deposition in a representative nasal airway model
Shi, H. and Kleinstreuer, C. and Zhang, Z. (2008), Physics of Fluids (Woodbury, N.Y.), 20(1), .
Discussion: "Effects of various parameters on nanotluid thermal conductivity" ( Jang, S.P., and Choi, S.D.S., 2007, ASME J. heat transfer, 129, pp. 617-623)
Kleinstreuer, C. and Li, J. (2008), Journal of Heat Transfer, 130(2), .
Flow over a thin circular disk at low to moderate Reynolds numbers
Shenoy, A. R. and Kleinstreuer, C. (2008), Journal of Fluid Mechanics, 605(), 253-262.
Microfluidics of nano-drug delivery
Kleinstreuer, C. and Li, J. and Koo, J. (2008), International Journal of Heat and Mass Transfer, 51(23-24), 5590-5597.
Modeling airflow and particle transport/deposition in pulmonary airways
Kleinstreuer, C. and Zhang, Z. and Li, Z. (2008), Respiratory Physiology & Neurobiology, 163(1-3), 128-138.
Targeted drug-aerosol delivery in the human respiratory system
Kleinstreuer, C. and Zhang, Z. and Donohue, J. F. (2008), Annual Review of Biomedical Engineering, 10(), 195-220.
Thermal performance of nanofluid flow in microchannels
Li, J. and Kleinstreuer, C. (2008), International Journal of Heat and Fluid Flow, 29(4), 1221-1232.
A new methodology for targeting drug-aerosols in the human respiratory system
Kleinstreuer, C. and Zhang, Z. and Li, Z. and Roberts, W. L. and Rojas, C. (2008), International Journal of Heat and Mass Transfer, 51(23-24), 5578-5589.
A nonlinear effective thermal conductivity model for carbon nanotube and nanofiber suspensions
Koo, J. and Kang, Y. and Kleinstreuer, C. (2008), Nanotechnology, 19(37), .
Combined inertial and gravitational deposition of microparticles in small model airways of a human respiratory system
Kleinstreuer, C. and Zhang, Z. and Kim, C. S. (2007), Journal of Aerosol Science, 38(10), 1047-1061.
Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology
Kleinstreuer, C. and Shi, H. W. and Zhang, Z. (2007), Journal of Aerosol Medicine, 20(3), 294-309.
Fluid-structure interaction analyses of stented abdominal aortic aneurysms
Kleinstreuer, C. and Li, Z. and Farber, M. A. (2007), Annual Review of Biomedical Engineering, 9(), 169-204.
Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness
Shi, H. A. and Kleinstreuer, C. and Zhang, Z. (2007), Journal of Aerosol Science, 38(4), 398-419.
Particle deposition in the human tracheobronchial airways due to transient inspiratory flow patterns
Li, Z. and Kleinstreuer, C. and Zhang, Z. (2007), Journal of Aerosol Science, 38(6), 625-644.
Simulation and analysis of high-speed droplet spray dynamics
Shi, H. and Kleinstreuer, C. (2007), Journal of Fluids Engineering, 129(5), 621-633.
Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part I: Airflow patterns
Li, Z. and Kleinstreuer, C. and Zhang, Z. (2007), European Journal of Mechanics. B, Fluids, 26(5), 632-649.
Simulation of airflow fields and microparticle deposition in realistic human lung airway models. Part II: Particle transport and deposition
Li, Z. and Kleinstreuer, C. and Zhang, Z. (2007), European Journal of Mechanics. B, Fluids, 26(5), 650-668.
A comparison between different asymmetric abdominal aortic aneurysm morphologies employing computational fluid-structure interaction analysis
Li, Z. H. and Kleinstreuer, C. (2007), European Journal of Mechanics. B, Fluids, 26(5), 615-631.
Analysis and computer program for rupture-risk prediction of abdominal aortic aneurysms
Kleinstreuer, C. and Li, Z. H. (2006), Biomedical Engineering Online, 5(), .
Analysis of biomechanical factors affecting stent-graft migration in an abdominal aortic aneurysm model
Li, Z. and Kleinstreuer, C. (2006), Journal of Biomechanics, 39(12), 2264-2273.
Computational analysis of type II endoleaks in a stented abdominal aortic aneurysm model
Li, Z. and Kleinstreuer, C. (2006), Journal of Biomechanics, 39(14), 2573-2582.
Effects of major endoleaks on a stented abdominal aortic aneurysm
Li, Z. and Kleinstreuer, C. (2006), Journal of Biomechanical Engineering, 128(1), 59-68.
Isotonic and hypertonic saline droplet deposition in a human upper airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2006), Journal of Aerosol Medicine, 19(2), 184-198.
Laminar airflow and nanoparticle or vapor deposition in a human nasal cavity model
Shi, H. and Kleinstreuer, C. and Zhang, Z. (2006), Journal of Biomechanical Engineering, 128(5), 697-706.
Transport and uptake of MTBE and ethanol vapors in a human upper airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2006), Inhalation Toxicology, 18(3), 169-184.
Water vapor transport and its effects on the deposition of hygroscopic droplets in a human upper airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2006), Aerosol Science and Technology, 40(1), 52-67.
Analysis of surface roughness effects on heat transfer in micro-conduits
Koo, J. M. and Kleinstreuer, C. (2005), International Journal of Heat and Mass Transfer, 48(13), 2625-2634.
Blood flow and structure interactions in a stented abdominal aortic aneurysm model
Li, Z. H. and Kleinstreuer, C. (2005), Medical Engineering & Physics, 27(5), 369-382.
Comparison of micro- and nano-size particle depositions in a human upper airway model
Zhang, Z. and Kleinstreuer, C. and Donohue, J. F. and Kim, C. S. (2005), Journal of Aerosol Science, 36(2), 211-233.
Computational analysis of biomechanical contributors to endovascular graft failure
Li, Z. and Kleinstreuer, C. and Farber, M. (2005), Biomechanics and Modeling in Mechanobiology, 4(4), 221-234.
Computational models for simulating multicomponent aerosol evaporation in the upper respiratory airways
Longest, P. W. and Kleinstreuer, C. (2005), Aerosol Science and Technology, 39(2), 124-138.
Fluid-structure interaction effects on sac-blood pressure and wall stress in a stented aneurysm
Li, Z. and Kleinstreuer, C. (2005), Journal of Biomechanical Engineering, 127(4), 662-671.
Laminar nanofluid flow in microheat-sinks
Koo, J. M. and Kleinstreuer, C. (2005), International Journal of Heat and Mass Transfer, 48(13), 2652-2661.
Numerical simulation of wall shear stress and particle-based hemodynamic parameters in pre-cuffed and streamlined end-to-side anastomoses
Longest, P. W. and Kleinstreuer, C. and Deanda, A. (2005), Annals of Biomedical Engineering, 33(12), 1752-1766.
A new wall stress equation for aneurysm-rupture prediction
Li, Z. and Kleinstreuer, C. (2005), Annals of Biomedical Engineering, 33(2), 209-213.
Airflow structures and nano-particle deposition in a human upper airway model
Zhang, Z. and Kleinstreuer, C. (2004), Journal of Computational Physics, 198(1), 178-210.
Computational analysis of wall roughness effects for liquid flow in micro-conduits
Kleinstreuer, C. and Koo, J. (2004), Journal of Fluids Engineering, 126(1), 09-.
Efficient computation of micro-particle dynamics including wall effects
Longest, P. W. and Kleinstreuer, C. and Buchanan, J. R. (2004), Computers & Fluids, 33(4), 577-601.
Interacting effects of uniform flow, plane shear, and near-wall proximity on the heat and mass transfer of respiratory aerosols
Longest, P. W. and Kleinstreuer, C. (2004), International Journal of Heat and Mass Transfer, 47(22), 4745-4759.
Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions
Shi, H. and Kleinstreuer, C. and Zhang, Z. and Kim, C. S. (2004), Physics of Fluids (Woodbury, N.Y.), 16(7), 2199-2213.
Particle-hemodynamics simulations and design options for surgical reconstruction of diseased carotid artery bifurcations
Hyun, S. and Kleinstreuer, C. and Longest, P. W. and Chen, C. (2004), Journal of Biomechanical Engineering, 126(2), 188-195.
Vaporizing microdroplet inhalation, transport, and deposition in a human upper airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. and Cheng, Y. S. (2004), Aerosol Science and Technology, 38(1), 36-49.
Viscous dissipation effects in microtubes and microchannels
Koo, J. M. and Kleinstreuer, C. (2004), International Journal of Heat and Mass Transfer, 47(14-16), 3159-3169.
A new thermal conductivity model for nanofluids
Koo, J. M. and Kleinstreuer, C. (2004), Journal of Nanoparticle Research, 6(6), 577-588.
Comparison of blood particle deposition models for non-parallel flow domains
Longest, P. W. and Kleinstreuer, C. (2003), Journal of Biomechanics, 36(3), 421-430.
Computational thermodynamics analysis of vaporizing fuel droplets in the human upper airways
Zhang, Z. and Kleinstreuer, C. (2003), JSME International Journal. Series B, Fluids and Thermal Engineering, 46(4), 563-571.
Hemodynamics simulation and identification of susceptible sites of atherosclerotic lesion formation in a model abdominal aorta
Buchanan, J. R. and Kleinstreuer, C. and Hyun, S. and Truskey, G. A. (2003), Journal of Biomechanics, 36(8), 1185-1196.
Laminar-to-turbulent fluid-particle flows in a human airway model
Kleinstreuer, C. and Zhang, Z. (2003), International Journal of Multiphase Flow, 29(2), 271-289.
Liquid flow in microchannels: experimental observations and computational analyses of microfluidics effects
Koo, J. M. and Kleinstreuer, C. (2003), Journal of Micromechanics and Microengineering, 13(5), 568-579.
Low-Reynolds-number turbulent flows in locally constricted conduits: A comparison study
Zhang, Z. and Kleinstreuer, C. (2003), AIAA Journal, 41(5), 831-840.
Numerical simulation of wall shear stress conditions and platelet localization in realistic end-to-side arterial anastomoses
Longest, P. W. and Kleinstreuer, C. (2003), Journal of Biomechanical Engineering, 125(5), 671-681.
Particle hemodynamics analysis of Miller cuff arterial anastomosis
Longest, P. W. and Kleinstreuer, C. and Archie, J. P. (2003), Journal of Vascular Surgery, 38(6), 1353-1362.
Particle-hemodynamics modeling of the distal end-to-side femoral bypass: effects of graft caliber and graft-end cut
Longest, P. W. and Kleinstreuer, C. (2003), Medical Engineering & Physics, 25(10), 843-858.
Relation between near-wall residence times of monocytes and early lesion growth in the rabbit aorto-celiac junction
Longest, P. W. and Kleinstreuer, C. and Truskey, G. A. and Buchanan, J. R. (2003), Annals of Biomedical Engineering, 31(1), 53-64.
Species heat and mass transfer in a human upper airway model
Zhang, Z. and Kleinstreuer, C. (2003), International Journal of Heat and Mass Transfer, 46(25), 4755-4768.
Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors
Kleinstreuer, C. and Zhang, Z. (2003), Journal of Biomechanical Engineering, 125(2), 197-206.
Acoustic streaming induced by ultrasonic flexural vibrations and associated enhancement of convective heat transfer
Loh, B. G. and Hyun, S. and Ro, P. I. and Kleinstreuer, C. (2002), Journal of the Acoustical Society of America, 111(2), 875-883.
Aerosol deposition efficiencies and upstream release positions for different inhalation modes in an upper bronchial airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2002), Aerosol Science and Technology, 36(7), 828-844.
Aerosol transport and deposition in a triple bifurcation bronchial airway model with local tumors
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. and Hickey, A. J. (2002), Inhalation Toxicology, 14(11), 1111-1133.
Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2002), Journal of Aerosol Science, 33(2), 257-281.
Gas-solid two-phase flow in a triple bifurcation lung airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2002), International Journal of Multiphase Flow, 28(6), 1021-1046.
Micro-particle transport and deposition in a human oral airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2002), Journal of Aerosol Science, 33(12), 1635-1652.
Transient airflow structures and particle transport in a sequentially branching lung airway model
Zhang, Z. and Kleinstreuer, C. (2002), Physics of Fluids (Woodbury, N.Y.), 14(2), 862-880.
Computational particle-hemodynamics analysis and geometric reconstruction after carotid endarterectomy
Hyun, S. and Kleinstreuer, C. and Archie, J. P. (2001), Computers in Biology and Medicine, 31(5), 365-384.
Effect of particle inlet distributions on deposition in a triple bifurcation lung airway model
Zhang, Z. and Kleinstreuer, C. (2001), Journal of Aerosol Medicine, 14(1), 13-29.
Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways, by Z. Zhang, C. Kleinstreuer and C. S.Kim - Response
Kleinstreuer, C. (2001), Journal of Medical Engineering & Technology, 25(3), 127.
Effects of curved inlet tubes on air flow and particle deposition in bifurcating lung models
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2001), Journal of Biomechanics, 34(5), 659-669.
Flow structure and particle transport in a triple bifurcation airway model
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2001), Journal of Fluids Engineering, 123(2), 320-330.
Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields
Comer, J. K. and Kleinstreuer, C. and Zhang, Z. (2001), Journal of Fluid Mechanics, 435(2001 May 25), 25-54.
Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition
Comer, J. K. and Kleinstreuer, C. and Kim, C. S. (2001), Journal of Fluid Mechanics, 435(2001 May 25), 55-80.
Hemodynamic parameters and early intimal thickening in branching blood vessels
Kleinstreuer, C. and Hyun, S. and Buchanan, J. R. and Longest, P. W. and Archie, J. P. and Truskey, G. A. (2001), Critical Reviews in Biomedical Engineering, 29(1), 1-64.
Numerical simulation of mixed convection heat and mass transfer in a human inhalation test chamber
Hyun, S. and Kleinstreuer, C. (2001), International Journal of Heat and Mass Transfer, 44(12), 2247-2260.
Aerosol transport and deposition in sequentially bifurcating airways
Comer, J. K. and Kleinstreuer, C. and Hyun, S. and Kim, C. S. (2000), Journal of Biomechanical Engineering, 122(2), 152-158.
Computational analyses and design improvements of graft-to-vein anastomoses
Longest, P. W. and Kleinstreuer, C. and Andreotti, P. J. (2000), CRC Critical Reviews in Biomedical Engineering, 28(1-2), 141-147.
Computational haemodynamics analysis and comparison study of arterio-venous grafts
Longest, P. W. and Kleinstreuer, C. (2000), Journal of Medical Engineering & Technology, 24(3), 102-110.
Computer simulation and geometric design of endarterectomized carotid artery bifurcations
Hyun, S. and Kleinstreuer, C. and Archie, J. P. (2000), CRC Critical Reviews in Biomedical Engineering, 28(1-2), 53-59.
Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways
Zhang, Z. and Kleinstreuer, C. and Kim, C. S. (2000), Journal of Medical Engineering & Technology, 24(5), 192-202.
Hemodynamics analyses of arterial expansions with implications to thrombosis and restenosis
Hyun, S. and Kleinstreuer, C. and Archie, J.P. (2000), Medical Engineering & Physics, 22(1), 13-27.
Rheological effects on pulsatile hemodynamics in a stenosed tube
Buchanan, J. R. and Kleinstreuer, C. and Comer, J. K. (2000), Computers & Fluids, 29(6), 695-724.
Turbulent three-dimensional air flow and trace gas distribution in an inhalation test chamber
Longest, P. W. and Kleinstreuer, C. and Kinsey, J. S. (2000), Journal of Fluids Engineering, 122(2), 403-411.
Relation between non-uniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction
Buchanan, J. R. and Kleinstreuer, C. and Truskey, G. A. and Lei, M. (1999), Atherosclerosis, 143(1), 27-40.
Analytical solution to flux enhancement in laminar concentrically stratified pipe flow of Bingham and Newtonian fluids
Buchanan, C. D. and Kleinstreuer, C. and Longest, P. W. (1998), Journal of Fluids Engineering, 120(3), 629-631.
Simulation of particle-hemodynamics in a partially occluded artery segment with implications to the initiation of microemboli and secondary stenoses
Buchanan, J. R. and Kleinstreuer, C. (1998), Journal of Biomechanical Engineering, 120(4), 446-454.
Computational design of a bypass graft that minimizes wall shear stress gradients in the region of the distal anastomosis
Lei, M. and Archie, J. P. and Kleinstreuer, C. (1997), Journal of Vascular Surgery, 25(4), 637-646.
Hemodynamic simulations and computer-aided designs of graft-artery junctions
Lei, M. and Kleinstreuer, C. and Archie, J. P. (1997), Journal of Biomechanical Engineering, 119(3), 343-348.

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Grants

Nasal Mucociliary Clearance Affecting Local Drug-Absorption in Subject-Specific Geometries
US Dept. of Health & Human Services (DHHS)(9/01/18 - 8/31/19)
A Predictive Open-Source Computer Model For Inhaled Nanoparticle Transport and Deposition in Subject-Specific Upper Airways
National Science Foundation (NSF)(9/01/12 - 8/31/15)
Computational Deposition Predictions of Multi-component Liquid Aerosols from Next-Generation Products in Human Respiratory Systems
Philip Morris Products S.A.(11/30/-1 - 3/31/12)
Experimentally Validated Numerical Models of Nanomaterials
National Science Foundation (NSF)(9/01/08 - 8/31/12)
Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
US Air Force (USAF)(8/01/07 - 7/31/11)
A Smart Inhaler System for Maximum Drug Aerosol Delivery
National Institutes of Health (NIH)(8/01/05 - 7/31/08)
Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
US Air Force (USAF)(8/01/04 - 7/31/07)
Micron & Submicron Aerosol Transport in Representative Human Nasal Airways
National Science Foundation (NSF)(7/15/02 - 7/31/09)