Clement Kleinstreuer

Professor

Adjunct Professor of Biomedical Engineering, NCSU and UNC Chapel Hill

Professor Kleinstreuer’s long-term goal is to provide students with a high-quality education in engineering and to perform cutting-edge research that responds to national needs in science and technology.

He recently developed the graduate-level course entitled “Modern Topics in Fluid Dynamics” (MAE 589K). This course treats such modern topics as microfluidics, bio-fluids, and nanofluid flow. At the undergraduate level, he teaches Engineering Thermodynamics I (MAE 301) as well as Fluid Mechanics (MAE 308). Although these are courses that follow a classical coverage of material, he also presents energy transfer and fluid-particle flow animations to help students visualize the different phenomena being treated. Furthermore, Student White-Board Performance (SW-BP) is an integral feature of advanced learning.

As a faculty advisor, Dr. Kleinstreuer guides his students to meet industrial and academic challenges. His students have a strong knowledge base in physics, applied mathematics, and gain a strong foundation in computer modeling of complex multi-physics phenomena.

Outside of work, Dr. Kleinstreuer enjoys family activities such as tennis, chess, sailing, and the arts.

Education

Ph.D.

Vanderbilt University

M.S.

Stanford University

Dipl.Ing

Technical University, Munich

Research Description

Dr. Kleinstreuer is interested in computational biofluid mechanics, convection heat and mass transfer, and system optimization. He is presently studying computationally: 1) fluid-particle dynamics in the human respiratory system, including optimal targeting of inhaled drug aerosols; 2) radioactive micro-sphere transport in the hepatic system to reduce/eliminate liver tumors; 3) fluid-structure interaction in stented aneurysms, associated with rupture prediction and novel stent-graft design; and 4) nanofluid flow in micro-channels applied to cooling devices and bio-MEMS.

Publications

Comparison of micron- and nano-particle transport in the human nasal cavity with a focus on the olfactory region
Vachhani, S., & Kleinstreuer, C. (2021), COMPUTERS IN BIOLOGY AND MEDICINE, 128. https://doi.org/10.1016/j.compbiomed.2020.104103
Computational analysis of a 3D mucociliary clearance model predicting nasal drug uptake
Chari, S., Sridhar, K., Walenga, R., & Kleinstreuer, C. (2021), JOURNAL OF AEROSOL SCIENCE. https://doi.org/10.1016/j.jaerosci.2021.105757
Helical fluid-particle flow dynamics for controlling micron-particle deposition in a representative human upper lung-airway model
Gurumurthy, A., & Kleinstreuer, C. (2021), JOURNAL OF AEROSOL SCIENCE, 151. https://doi.org/10.1016/j.jaerosci.2020.105656
High-temperature effects on the mucus layers in a realistic human upper airway model
Kulkarni, N. A., & Kleinstreuer, C. (2020), INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 163. https://doi.org/10.1016/j.ijheatmasstransfer.2020.120467
A new collision model for ellipsoidal particles in shear flow
Saini, N., & Kleinstreuer, C. (2019), JOURNAL OF COMPUTATIONAL PHYSICS, 376, 1028–1050. https://doi.org/10.1016/j.jcp.2018.09.039
Heterogeneous blood flow in microvessels with applications to nanodrug transport and mass transfer into tumor tissue
Xu, Z., & Kleinstreuer, C. (2019), BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 18(1), 99–110. https://doi.org/10.1007/s10237-018-1071-2
Mice-to-men comparison of inhaled drug-aerosol deposition and clearance
Kolanjiyil, A. V., Kleinstreuer, C., Kleinstreuer, N. C., Pham, W., & Sadikot, R. T. (2019), RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 260, 82–94. https://doi.org/10.1016/j.resp.2018.11.003
Modeling Airflow and Particle Deposition in a Human Acinar Region
Kolanjiyil, A. V., & Kleinstreuer, C. (2019), COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE. https://doi.org/10.1155/2019/5952941
Recent advances in modeling and simulation of nanofluid flows-Part I: Fundamentals and theory
Mahian, O., Kolsi, L., Amani, M., Estelle, P., Ahmadi, G., Kleinstreuer, C., … Pop, L. (2019). [Review of , ]. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 790, 1–48. https://doi.org/10.1016/j.physrep.2018.11.004
Recent advances in modeling and simulation of nanofluid flows-Part II: Applications
Mahian, O., Kolsi, L., Amani, M., Estelle, P., Ahmadi, G., Kleinstreuer, C., … Pop, I. (2019). [Review of , ]. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 791, 1–59. https://doi.org/10.1016/j.physrep.2018.11.003

View all publications via NC State Libraries

Grants

Nasal Mucociliary Clearance Affecting Local Drug-Absorption in Subject-Specific Geometries
(9/01/18 - 8/31/21)
A Predictive Open-Source Computer Model For Inhaled Nanoparticle Transport and Deposition in Subject-Specific Upper Airways
(9/01/12 - 8/31/15)
Computational Deposition Predictions of Multi-component Liquid Aerosols from Next-Generation Products in Human Respiratory Systems
(11/30/-1 - 3/31/12)
Experimentally Validated Numerical Models of Nanomaterials
(9/01/08 - 8/31/12)
Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
(8/01/07 - 7/31/11)
A Smart Inhaler System for Maximum Drug Aerosol Delivery
(8/01/05 - 7/31/08)
Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
(8/01/04 - 7/31/07)
Micron & Submicron Aerosol Transport in Representative Human Nasal Airways
(7/15/02 - 7/31/09)