Clement Kleinstreuer


Adjunct Professor of Biomedical Engineering, NCSU and UNC Chapel Hill

Professor Kleinstreuer’s long-term goal is to provide students with a high-quality education in engineering and to perform cutting-edge research that responds to national needs in science and technology.

He recently developed the graduate-level course entitled “Modern Topics in Fluid Dynamics” (MAE 589K). This course treats such modern topics as microfluidics, bio-fluids, and nanofluid flow. At the undergraduate level, he teaches Engineering Thermodynamics I (MAE 301) as well as Fluid Mechanics (MAE 308). Although these are courses that follow a classical coverage of material, he also presents energy transfer and fluid-particle flow animations to help students visualize the different phenomena being treated. Furthermore, Student White-Board Performance (SW-BP) is an integral feature of advanced learning.

As a faculty advisor, Dr. Kleinstreuer guides his students to meet industrial and academic challenges. His students have a strong knowledge base in physics, applied mathematics, and gain a strong foundation in computer modeling of complex multi-physics phenomena.

Outside of work, Dr. Kleinstreuer enjoys family activities such as tennis, chess, sailing, and the arts.



Vanderbilt University


Stanford University


Technical University, Munich

Research Description

Dr. Kleinstreuer is interested in computational biofluid mechanics, convection heat and mass transfer, and system optimization. He is presently studying computationally: 1) fluid-particle dynamics in the human respiratory system, including optimal targeting of inhaled drug aerosols; 2) radioactive micro-sphere transport in the hepatic system to reduce/eliminate liver tumors; 3) fluid-structure interaction in stented aneurysms, associated with rupture prediction and novel stent-graft design; and 4) nanofluid flow in micro-channels applied to cooling devices and bio-MEMS.


A new collision model for ellipsoidal particles in shear flow
Saini, N., & Kleinstreuer, C. (2019), JOURNAL OF COMPUTATIONAL PHYSICS, 376, 1028–1050.
Mice-to-men comparison of inhaled drug-aerosol deposition and clearance
Kolanjiyil, A. V., Kleinstreuer, C., Kleinstreuer, N. C., Pham, W., & Sadikot, R. T. (2019), RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 260, 82–94.
Modeling Airflow and Particle Deposition in a Human Acinar Region
An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition
Feng, Y., Zhao, J., Kleinstreuer, C., Wang, Q., Wang, J., Wu, D. H., & Lin, J. (2018), JOURNAL OF AEROSOL SCIENCE, 123, 185–207.
Convective mass and heat transfer enhancement of nanofluid streams in bifurcating microchannels
Chari, S., & Kleinstreuer, C. (2018), INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 125, 1212–1229.
Direct nanodrug delivery for tumor targeting subject to shear-augmented diffusion in blood flow
Xu, Z., & Kleinstreuer, C. (2018), MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 56(11), 1949–1958.
Subject-variability effects on micron particle deposition in human nasal cavities
Calmet, H., Kleinstreuer, C., Houzeaux, G., Kolanjiyil, A. V., Lehmkuhl, O., Olivares, E., & Vazquez, M. (2018), Journal of Aerosol Science, 115, 12–28.
Computational analysis of aerosol-dynamics in a human whole-lung airway model
Kolanjiyil, A. V., & Kleinstreuer, C. (2017), Journal of Aerosol Science, 114, 301–316.
Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model
Chen, X. L., Feng, Y., Zhong, W. Q., & Kleinstreuer, C. (2017), Journal of Aerosol Science, 105, 108–127.
Computational nanofluid flow and heat transfer in microchannels
Kleinstreuer, C. (2016), Handbook of Fluid Dynamics, 2nd Edition.

View all publications via NC State Libraries


Nasal Mucociliary Clearance Affecting Local Drug-Absorption in Subject-Specific Geometries
US Dept. of Health & Human Services (DHHS)(9/01/18 - 8/31/19)
A Predictive Open-Source Computer Model For Inhaled Nanoparticle Transport and Deposition in Subject-Specific Upper Airways
National Science Foundation (NSF)(9/01/12 - 8/31/15)
Computational Deposition Predictions of Multi-component Liquid Aerosols from Next-Generation Products in Human Respiratory Systems
Philip Morris Products S.A.(11/30/-1 - 3/31/12)
Experimentally Validated Numerical Models of Nanomaterials
National Science Foundation (NSF)(9/01/08 - 8/31/12)
Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
US Air Force (USAF)(8/01/07 - 7/31/11)
A Smart Inhaler System for Maximum Drug Aerosol Delivery
National Institutes of Health (NIH)(8/01/05 - 7/31/08)
Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
US Air Force (USAF)(8/01/04 - 7/31/07)
Micron & Submicron Aerosol Transport in Representative Human Nasal Airways
National Science Foundation (NSF)(7/15/02 - 7/31/09)