Clement Kleinstreuer
Professor
Adjunct Professor of Biomedical Engineering, NCSU and UNC Chapel Hill

- 919-515-5261
- ck@ncsu.edu
- Engineering Building III (EB3) 4176
- Visit My Website
Professor Kleinstreuer’s long-term goal is to provide students with a high-quality education in engineering and to perform cutting-edge research that responds to national needs in science and technology.
He recently developed the graduate-level course entitled “Modern Topics in Fluid Dynamics” (MAE 589K). This course treats such modern topics as microfluidics, bio-fluids, and nanofluid flow. At the undergraduate level, he teaches Engineering Thermodynamics I (MAE 301) as well as Fluid Mechanics (MAE 308). Although these are courses that follow a classical coverage of material, he also presents energy transfer and fluid-particle flow animations to help students visualize the different phenomena being treated. Furthermore, Student White-Board Performance (SW-BP) is an integral feature of advanced learning.
As a faculty advisor, Dr. Kleinstreuer guides his students to meet industrial and academic challenges. His students have a strong knowledge base in physics, applied mathematics, and gain a strong foundation in computer modeling of complex multi-physics phenomena.
Outside of work, Dr. Kleinstreuer enjoys family activities such as tennis, chess, sailing, and the arts.
Education
Vanderbilt University
Stanford University
Technical University, Munich
Research Description
Dr. Kleinstreuer is interested in computational biofluid mechanics, convection heat and mass transfer, and system optimization. He is presently studying computationally: 1) fluid-particle dynamics in the human respiratory system, including optimal targeting of inhaled drug aerosols; 2) radioactive micro-sphere transport in the hepatic system to reduce/eliminate liver tumors; 3) fluid-structure interaction in stented aneurysms, associated with rupture prediction and novel stent-graft design; and 4) nanofluid flow in micro-channels applied to cooling devices and bio-MEMS.
Publications
- Comparison of micron- and nano-particle transport in the human nasal cavity with a focus on the olfactory region
- Vachhani, S., & Kleinstreuer, C. (2021), COMPUTERS IN BIOLOGY AND MEDICINE, 128. https://doi.org/10.1016/j.compbiomed.2020.104103
- Helical fluid-particle flow dynamics for controlling micron-particle deposition in a representative human upper lung-airway model
- Gurumurthy, A., & Kleinstreuer, C. (2021), JOURNAL OF AEROSOL SCIENCE, 151. https://doi.org/10.1016/j.jaerosci.2020.105656
- High-temperature effects on the mucus layers in a realistic human upper airway model
- Kulkarni, N. A., & Kleinstreuer, C. (2020), INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 163. https://doi.org/10.1016/j.ijheatmasstransfer.2020.120467
- A new collision model for ellipsoidal particles in shear flow
- Saini, N., & Kleinstreuer, C. (2019), JOURNAL OF COMPUTATIONAL PHYSICS, 376, 1028–1050. https://doi.org/10.1016/j.jcp.2018.09.039
- Heterogeneous blood flow in microvessels with applications to nanodrug transport and mass transfer into tumor tissue
- Xu, Z., & Kleinstreuer, C. (2019), BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 18(1), 99–110. https://doi.org/10.1007/s10237-018-1071-2
- Mice-to-men comparison of inhaled drug-aerosol deposition and clearance
- Kolanjiyil, A. V., Kleinstreuer, C., Kleinstreuer, N. C., Pham, W., & Sadikot, R. T. (2019), RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 260, 82–94. https://doi.org/10.1016/j.resp.2018.11.003
- Modeling Airflow and Particle Deposition in a Human Acinar Region
- Kolanjiyil, A. V., & Kleinstreuer, C. (2019), COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE. https://doi.org/10.1155/2019/5952941
- Recent advances in modeling and simulation of nanofluid flows-Part I: Fundamentals and theory
- Mahian, O., Kolsi, L., Amani, M., Estelle, P., Ahmadi, G., Kleinstreuer, C., … Pop, L. (2019). [Review of , ]. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 790, 1–48. https://doi.org/10.1016/j.physrep.2018.11.004
- Recent advances in modeling and simulation of nanofluid flows-Part II: Applications
- Mahian, O., Kolsi, L., Amani, M., Estelle, P., Ahmadi, G., Kleinstreuer, C., … Pop, I. (2019). [Review of , ]. PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 791, 1–59. https://doi.org/10.1016/j.physrep.2018.11.003
- An in silico inter-subject variability study of extra-thoracic morphology effects on inhaled particle transport and deposition
- Feng, Y., Zhao, J., Kleinstreuer, C., Wang, Q., Wang, J., Wu, D. H., & Lin, J. (2018), JOURNAL OF AEROSOL SCIENCE, 123, 185–207. https://doi.org/10.1016/j.jaerosci.2018.05.010
Grants
- Nasal Mucociliary Clearance Affecting Local Drug-Absorption in Subject-Specific Geometries
- US Dept. of Health & Human Services (DHHS)(9/01/18 - 8/31/21)
- A Predictive Open-Source Computer Model For Inhaled Nanoparticle Transport and Deposition in Subject-Specific Upper Airways
- National Science Foundation (NSF)(9/01/12 - 8/31/15)
- Computational Deposition Predictions of Multi-component Liquid Aerosols from Next-Generation Products in Human Respiratory Systems
- Philip Morris Products S.A.(11/30/-1 - 3/31/12)
- Experimentally Validated Numerical Models of Nanomaterials
- National Science Foundation (NSF)(9/01/08 - 8/31/12)
- Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
- US Air Force (USAF)(8/01/07 - 7/31/11)
- A Smart Inhaler System for Maximum Drug Aerosol Delivery
- National Institutes of Health (NIH)(8/01/05 - 7/31/08)
- Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
- US Air Force (USAF)(8/01/04 - 7/31/07)
- Micron & Submicron Aerosol Transport in Representative Human Nasal Airways
- National Science Foundation (NSF)(7/15/02 - 7/31/09)