Clement Kleinstreuer


Adjunct Professor of Biomedical Engineering, NCSU and UNC Chapel Hill

Professor Kleinstreuer’s long-term goal is to provide students with a high-quality education in engineering and to perform cutting-edge research that responds to national needs in science and technology.

He recently developed the graduate-level course entitled “Modern Topics in Fluid Dynamics” (MAE 589K). This course treats such modern topics as microfluidics, bio-fluids, and nanofluid flow. At the undergraduate level, he teaches Engineering Thermodynamics I (MAE 301) as well as Fluid Mechanics (MAE 308). Although these are courses that follow a classical coverage of material, he also presents energy transfer and fluid-particle flow animations to help students visualize the different phenomena being treated. Furthermore, Student White-Board Performance (SW-BP) is an integral feature of advanced learning.

As a faculty advisor, Dr. Kleinstreuer guides his students to meet industrial and academic challenges. His students have a strong knowledge base in physics, applied mathematics, and gain a strong foundation in computer modeling of complex multi-physics phenomena.

Outside of work, Dr. Kleinstreuer enjoys family activities such as tennis, chess, sailing, and the arts.



Vanderbilt University


Stanford University


Technical University, Munich

Research Description

Dr. Kleinstreuer is interested in computational biofluid mechanics, convection heat and mass transfer, and system optimization. He is presently studying computationally: 1) fluid-particle dynamics in the human respiratory system, including optimal targeting of inhaled drug aerosols; 2) radioactive micro-sphere transport in the hepatic system to reduce/eliminate liver tumors; 3) fluid-structure interaction in stented aneurysms, associated with rupture prediction and novel stent-graft design; and 4) nanofluid flow in micro-channels applied to cooling devices and bio-MEMS.


Numerical investigation of the interaction, transport and deposition of multicomponent droplets in a simple mouth-throat model
Chen, X. L., Feng, Y., Zhong, W. Q., & Kleinstreuer, C. (2017), Journal of Aerosol Science, 105, 108-127.
Computational nanofluid flow and heat transfer in microchannels
Kleinstreuer, C. (2016), Handbook of Fluid Dynamics, 2nd Edition, .
Microsystems and microfluidics
Kleinstreuer, C. (2016), Handbook of Fluid Dynamics, 2nd Edition, .
Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation
Kolanjiyil, A. V., & Kleinstreuer, C. (2016), Computers in Biology and Medicine, 79, 193-204.
Laminar/turbulent airflow and microsphere deposition in a patient-specific airway geometry using an open-source solver
Vaish, M., Kleinstreuer, C., Kolanjiyil, A. V., Saini, N., & Pillalamarri, N. R. (2016), International Journal of Biomedical Engineering and Technology, 22(2), 145-161.
Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model
Chen, X. L., Zhong, W. Q., Tom, J., Kleinstreuer, C., Feng, Y., & He, X. P. (2016), Particuology, 28, 102-113.
Computational transport, phase change and deposition analysis of inhaled multicomponent droplet-vapor mixtures in an idealized human upper lung model
Feng, Y., Kleinstreuer, C., Castro, N., & Rostami, A. (2016), Journal of Aerosol Science, 96, 96-123.
Solid tumor embolotherapy in hepatic arteries with an anti-reflux catheter system
Xu, Z. L., Jernigan, S., Kleinstreuer, C., & Buckner, G. D. (2016), Annals of Biomedical Engineering, 44(4), 1036-1046.
A Lagrangian approach for calculating microsphere deposition in a one-dimensional lung-airway model
Vaish, M., & Kleinstreuer, C. (2015), Journal of Biomechanical Engineering, 137(9).
Computationally efficient fluid-particle dynamics simulations of arterial systems
Umbarkar, T. S., & Kleinstreuer, C. (2015), Communications in Computational Physics, 17(2), 401-423.

View all publications via NC State Libraries


Computational Analysis of Lung-Aerosol Dynamics with Applications
Altria Client Services Inc.(10/01/13 - 12/31/15)
A Predictive Open-Source Computer Model For Inhaled Nanoparticle Transport and Deposition in Subject-Specific Upper Airways
National Science Foundation (NSF)(9/01/12 - 8/31/15)
Computational Deposition Predictions of Multi-component Liquid Aerosols from Next-Generation Products in Human Respiratory Systems
Philip Morris Products S.A.(11/30/-1 - 3/31/12)
Experimentally Validated Numerical Models of Nanomaterials
National Science Foundation (NSF)(9/01/08 - 8/31/12)
Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
US Air Force (USAF)(8/01/07 - 7/31/11)
A Smart Inhaler System for Maximum Drug Aerosol Delivery
National Institutes of Health (NIH)(8/01/05 - 7/31/08)
Computational Studies of JP-8 Fuel Aerosol and Toxic Nanomaterial Transport/Deposition in Models of the Human Respiratory System
US Air Force (USAF)(8/01/04 - 7/31/07)
Micron & Submicron Aerosol Transport in Representative Human Nasal Airways
National Science Foundation (NSF)(7/15/02 - 7/31/09)